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Generic Actos (Pioglitazone) is a member of the type of oral diabetes agents called thiazolidinediones (THIGH-ah-ZO-li-deen-DYE-owns; TZDs). These medications help reduce insulin resistance, which has been identified as one of the major problems in type 2 diabetes.

Generic Actos (Pioglitazone) is a once-a-day prescription pill for type 2 diabetes that along with healthy eating and physical activity helps your body more effectively use its own natural insulin or the insulin you take. When your necessary efforts at healthy eating and physical activity alone do not control your blood glucose levels, ACTOS can be used by itself or in combination with certain other diabetes pills (sulfonylureas, metformin) or insulin to lower blood glucose

Active Ingredients: pioglitazone
Other Ingredients: lactose monohydrate NF, hydroxypropylcellulose NF, arboxymethylcellulose calcium NF, and magnesium stearate NF.
Class and Mechanism: Generic Actos (Pioglitazone) is a thiazolidinedione antidiabetic agent that depends on the presence of insulin for its mechanism of action. Generic Actos (Pioglitazone) decreases insulin resistance in the periphery and in the liver resulting in increased insulin-dependent glucose disposal and decreased hepatic glucose output. Unlike sulfonylureas, pioglitazone is not an insulin secretagogue. Pioglitazone is a potent and highly selective agonist for peroxisome proliferatoractivated receptor-gamma (PPAR?). PPAR receptors are found in tissues important for insulin action such as adipose tissue, skeletal muscle, and liver. Activation of PPAR? nuclear receptors modulates the transcription of a number of insulin responsive genes involved in the control of glucose and lipid metabolism. The metabolic changes produced by pioglitazone result in increased responsiveness of insulin-dependent tissues and are observed in numerous animal models of insulin resistance.

Keep out of the reach of children in a container that small children cannot open. Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed and protect from moisture and humidity. Throw away any unused medicine after the expiration date.

Take this medication by mouth, with or without food, usually once daily, or as directed by your doctor. Dosage is based on your medical condition, response to therapy, and if you are taking other anti-diabetic drugs. Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time(s) each day. Monitor blood glucose levels on a regular basis. It may take up to 2 to 3 months before the full benefit of this drug takes effect. Take all other medications for diabetes as directed by your doctor.
When OVERDOSE is suspected contact your local poison control center or emergency room immediately. Symptoms of overdose may include nausea, diarrhea, stomach distress, and indigestion.

Take it as soon as you remember. If you miss a dose on one day, skip it and go back to your regular schedule. Do not double your dose the following day.

Do not take Generic Actos (Pioglitazone) for Type 1 diabetes (juvenile diabetes) or diabetic ketoacidosis.
If you have heart failure, fluid retention or active liver disease your health care provider will evaluate you to decide if Generic Actos (Pioglitazone) is right for you.

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Generic Actos (Pioglitazone).
Side effects may include:
Headache, hypoglycemia, muscle aches, respiratory tract infection, sinus inflammation, sore throat, swelling, tooth disorder

Tell your doctor of all nonprescription and prescription medication you are using, especially: Generic Actos (Pioglitazone) may decrease the effects of some birth control pills. Additional measures may be necessary to prevent pregnancy while taking Generic Actos (Pioglitazone). Talk to your doctor about the use of birth control. Do not take over-the-counter or prescription cough, cold, allergy, pain, or weight-loss medications during treatment with Generic Actos (Pioglitazone) without first talking to your doctor. Drugs other than those listed here may also interact with Generic Actos (Pioglitazone).
Talk to your doctor and pharmacist before taking any prescription or over-the-counter medicines.

Many medications may cause changes (increase or decrease) in blood sugar, these include:
• alcohol containing beverages
• angiotensin converting enzyme inhibitors (ACE inhibitors), often used for high blood pressure or heart problems (examples: captopril, enalapril, lisinopril)
• antiretroviral protease inhibitors (examples: indinavir, ritonavir, saquinavir)
• aspirin and aspirin-like drugs
• baclofen
• beta-blockers, often used for high blood pressure or heart problems (examples include atenolol, metoprolol, propranolol)
• certain medicines used for mental depression, emotional, or psychotic disturbances
• chromium
• cisapride
• clonidine
• cyclosporine
• diazoxide
• disopyramide
• epinephrine
• female hormones, such as estrogens or progestins, birth control pills
• fibric acid derivatives, used to treat high cholesterol (examples: fenofibrate and gemfibrozil)
• glucagon
• growth hormone (somatropin)
• guanethidine
• isoniazid
• lithium
• metoclopramide
• male hormones or anabolic steroids
• medications to suppress appetite or for weight loss
• medicines for allergies, asthma, cold, or cough
• niacin
• nicotine (including nicotine found in patches and gum)
• octreotide
• pentamidine
• phenytoin
• quinolone antibiotics (examples: ciprofloxacin, levofloxacin, ofloxacin)
• some herbal dietary supplements
• steroid medicines such as prednisone or cortisone
• sulfonamides, medicines for infection (examples: Azulfidine®, Bactrim®, Gantrisin® Septra®)
• tacrolimus
• tegaserod
• thyroid hormones
• water pills (diuretics)

Tell your prescriber or health care professional about all other medicines you are taking, including non-prescription medicines, nutritional supplements, or herbal products. Also tell your prescriber or health care professional if you are a frequent user of drinks with caffeine or alcohol, if you smoke, or if you use illegal drugs. These may affect the way your medicine works. Check with your health care professional before stopping or starting any of your medicines.

Visit your prescriber or health care professional for regular checks on your progress. Learn how to monitor blood or urine sugar and urine ketones regularly.
Your health care professional will have to check blood tests regularly to assess the effect of this medication on your liver. Pioglitazone may rarely cause changes in some of these measurements. If you are going to have surgery, tell your prescriber or health care professional that you are taking pioglitazone. Wear a medical identification bracelet or chain to say you have diabetes, and carry a card that lists all your medications.